A study lead by Victor Faundez, Associate Professor of Cell Biology at Emory University reports the “Quantitative Proteomic and Genetic Analyses of the Schizophrenia Susceptibility Factor Dysbindin Identify Novel Roles of the Biogenesis of Lysosome-Related Organelles Complex 1” in The Journal of Neuroscience (14 March 2012, 32, 3637-3651). The Biogenesis of Lysosome-related Organelles Complex 1 (BLOC-1) is a protein complex containing the schizophrenia susceptibility factor dysbindin, which is encoded by the gene DTNBP1. Mechanisms engaged by dysbindin defining schizophrenia susceptibility pathways have not been previously quantitatively elucidated. The work which included a Stable Isotopes in Cell Culture (SILAC) component resulted in the discovery of prevalent and novel cellular roles of the BLOC-1 complex in neuronal cells. Professor Faundez enlisted the skills of MS Bioworks to provide mass spectrometry services for this project.
Congratulations to Avanti Gokhale, the leading author, and Victor’s team for furthering our understanding of Schizophrenia a devastating disorder for most people who are afflicted, and very costly for families and society as a whole.