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Custom-works

MS Bioworks is equipped with cutting edge analytical instrumentation suited to handling the diverse and demanding nature of modern proteomics experiments.  We understand that some projects fall outside of our routine service portfolio and as such we are happy to discuss custom projects and deliver a solution tailored to your needs.

Examples of recent custom services include:

“Determination of relative ratios of mutant and wild-type sarcomere proteins in human samples from patients with a genetic heart muscle condition”

Approach:

For this project we recommended developing a targeted selected reaction monitoring (SRM) assay.  We first demonstrated we were able to detect the normal and mutated peptides in diseased tissue using the LTQ-Velos-Orbitrap.  We then developed a selective, sensitive and precise targeted peptide assay using a TSQ Quantum Ultra triple quadrupole platform.  The assay was optimized using synthetic peptide standards and data were reported as a normal/mutant mole ratio for a fixed mass of tissue.

“MS Bioworks offers state of the art proteomic technology and consultation with highly experienced scientists who can taylor your project to answer very specific scientific questions. The turnaround time is fast and the pricing is very reasonable and competitive”

Sharlene Day, Director Hypertrophic Cardiomyopathy Clinic, University of Michigan, Ann Arbor, MI

We are happy to discuss the parameters of a custom project with you.