Latest News

Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma

Biomarker identification work by MS Bioworks scientists aids researchers at Barts Cancer Institute, Queen Mary University of London to develop a urine test for early stage pancreatic cancer.   A combination of three proteins found in urine can accurately detect early-stage pancreatic cancer, researchers from Queen Mary University of London have found. The discovery could lead […]

Target Identification Highlighted at AACR

The American Association for Cancer Research (AACR) annual meeting was held at the Pennsylvania Convention Center, Philadelphia, PA, USA.  The meeting highlights the latest, most exciting discoveries in every area of cancer research and provides an opportunity for investigators from all over the world to meet, interact and share their insights. MS Bioworks was exhibiting at […]

Annual Donation to C.S. Mott Children’s Hospital

On December 18th, MS Bioworks Co-Founders Ravi Amunugama and Michael Ford visited the C.S. Mott Children’s Hospital, part of the University of Michigan Health System to present Gene Skidmore, Assistant Director of Development for the University of Michigan Health System Office of Development with a check for $20,000 to support multiple programs at the hospital. […]

University of Michigan and MS Bioworks collaborate on development of an EMT-associated secretory phenotype (EASP) for prediction of survival in lung cancer patients

A recent study reported in Carcinogenesis by Venkat Keshamouni and colleagues at the University of Michigan, in collaboration with MS Bioworks, demonstrates the that integrative analysis of the critical biological process of epithelial–mesenchymal transition (EMT) provides mechanism-based and clinically relevant biomarkers with significant prognostic value. The study utilized a transforming growth factor-?-induced cell culture model […]

Addition of Agilent 1100 enables robust off-line fractionation

MS Bioworks recently acquired an Agilent 1100 Quaternary HPLC system with diode array detector (DAD) and fraction collector to expand our service offerings through utilizing offline fraction collection upstream to mass spectrometry. This acquisition has had an immediate impact in our deep profiling Phospho-screen plus service using strong cation exchange (SCX) prior to phosphopeptide enrichment.  […]

Second Q Exactive is online

This month we added another Thermo Fisher Q Exactive instrument, this new addition will allow us to exceed the capacity currently demanded by our clients.  We now have three Orbitrap instruments online and acquiring data 24hrs a day.  The new instrument is equipped with a Thermo Fisher Easy-nLC 1000, the pump that has recently been […]

American Society for Mass Spectrometry Annual Meeting

The sixty first American Society for Mass Spectrometry (ASMS) annual meeting was held at the Minneapolis Convention Center, Minneapolis, MN, USA.  As usual the conference was packed with the latest tools and techniques emerging from the mass spectrometry community.  MS Bioworks was exhibiting at booth #158 and we were happy to see some old friends […]

New Promega/MS Bioworks Pubhub article

PNGase F is an endoglycosidase that specifically removes N-linked glycans from glycoproteins. It is used extensively in workflows for characterizing N-linked glycan structures on therapeutic proteins and for identifying N-linked glycosylation sites in proteomic studies. We have expressed and purified recombinant PNGase F and shown that it is highly active against a variety of substrates, […]

University of Michigan Human Genetics Researcher Awarded R01 to Study Functional Genetics of the Neuronal Sodium Channel Gene SCN8A

Congratulations to Professor Miriam Meisler from the Department of Human Genetics at the University of Michigan for a recently awarded NIH R01 grant for a five year study – “Functional Genetics of the Neuronal Sodium Channel Gene SCN8A”.  Voltage-gated sodium channels are responsible for the rising phase of the action potential during neuronal firing. SCN8A […]

Fraunhofer scientists report expression in plants of an active bacterial PNGase F and the production of recombinant proteins of interest in a non-glycosylated form

Dr. Tarlan Mamedov and his colleagues from Fraunhofer USA Center for Molecular Biotechnology report their work on the production of non-glycosylated proteins in the Plant Biotechnology Journal. Tarlan and his colleagues use in-vivo deglycosylation of recombinant N glycosylated proteins as a result of their co-expression with bacterial PNGase F. Plasmodium parasites may have complex post-translationally […]

Michigan Scientists establish functional links between canonical Wnt signaling, Slug expression, EMT and BRCA1 regulation

Professor Stephen Weiss and his colleagues from the University of Michigan have established functional links between canonical Wnt signaling, Slug expression, EMT and BRCA1 regulation. Published in the Proceedings of the National Academy of Sciences the work identifies an unrecognized Wnt/GSK3?/?-Trcp axis that controls Slug activity. Slug (Snail2) plays critical roles in regulating the epithelial-mesenchymal […]