APP may act as a substrate and a recognition unit for CRL4CRBN and Stub1 E3 ligases facilitating ubiquitination of proteins involved in presynaptic functions and neurodegeneration More
The methylcytosine dioxygenase Ten-Eleven Translocase-2 (tet2) enables elevated GnRH gene expression and maintenance of male reproductive function More
Identification of dipeptidyl peptidase 3 as the Angiotensin-(1-7) degrading peptidase in human HK-2 renal epithelial cells More
Inherent ER stress in pancreatic islet ? cells causes self-recognition by autoreactive T cells in type 1 diabetes More
Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1? and improve limb revascularization More
Ubiquitination of neuronal nitric-oxide synthase in the calmodulin-binding site triggers proteasomal degradation of the protein More
Novel human-derived extracellular matrix induces in vitro and in vivo vascularization and inhibits fibrosis More
Lysine acetylation of the Mycobacterium tuberculosis HU protein modulates its DNA binding and genome organization More
Ingression Progression Complexes Control Extracellular Matrix Remodelling during Cytokinesis in Budding Yeast More